Synchronization of toggle switches coupled through a common inhibitor
Department of Physics, Chungbuk National University - Cheongju, Chungbuk 361-763, Korea
2 Department of System Research and Management, Institute of Information Technology, Vietnamese Academy of Science and Technology - Hanoi, Vietnam
Corresponding author: email@example.com
Accepted: 30 March 2010
We have investigated the synchronization of discrete jump events arising from two coupled toggle switches. The toggle switches, composed of positive-feedback loops with bistability, were coupled through two branches of double negative-feedback loops induced by a common inhibitor. From a bifurcation analysis of the coupled feedback systems, we show that there are two different mechanisms of synchronization. One is based on the merging of bistabilities and the other on the suppression of intrinsic bistability by the strong bistability induced by the common inhibitor. The dependence of the synchronization on the strength of the double negative-feedback loop is presented.
PACS: 05.45.Xt – Synchronization, coupled oscillators / 82.39.Rt – Reactions in complex biological systems / 87.18.Cf – Genetic switches and networks
© EPLA, 2010