The temperature dependence of the heat capacity of hydration water near biosurfaces from molecular simulations
Physical Chemistry, Dortmund University of Technology - Otto-Hahn-Str. 6, Dortmund, D-44227, Germany, EU
Corresponding author: firstname.lastname@example.org
Accepted: 26 April 2010
The temperature dependence of the components of the potential energy and specific heat Cp of the hydration water is studied by simulations of hydrophobic and hydrophilic peptides in water. In hydration shells of both peptides, the Cp of water exceeds the bulk value and decreases upon heating. At 330 K, the Cp of hydration water undergoes qualitative changes: the contribution of water-water interactions within the hydration shell to Cp sharply decreases, whereas the contribution due to interactions between hydration and bulk water to Cp sharply increases. These changes occur in the temperature interval where the hydrogen-bonded network of the hydration water breakes upon heating. The improved connectivity between the hydration water and bulk water at high temperatures makes the surface of biomolecules effectively more hydrophobic and may affect dynamics of biomolecules and their aggregation.
PACS: 68.35.Md – Surface thermodynamics, surface energies / 61.20.Ja – Computer simulation of liquid structure / 64.60.ah – Percolation
© EPLA, 2010