Dynamic phase transition in the conversion of B-DNA to Z-DNA
Institute of Physics - Bhubaneswar 751005, India
Accepted: 24 November 2010
The long time dynamics of the conformational transition from B-DNA to Z-DNA is shown to undergo a dynamic phase transition. We obtained the dynamic phase diagram for the stability of the front separating B and Z. The instability in this front results in two split fronts moving with different velocities. Hence, depending on the system parameters a denatured state may develop dynamically even though it is thermodynamically forbidden. This resolves the current controversies on the transition mechanism of the B-DNA to Z-DNA.
PACS: 87.14.gk – DNA / 87.15.hp – Conformational changes / 82.37.Rs – Single molecule manipulation of proteins and other biological molecules
© EPLA, 2010