Recovery of state-specific potential of molecular motor from single-molecule trajectory
Faculty of Science and Engineering, Chuo University - Tokyo 112-8551, Japan
2 Faculty of Physics, Ludwig-Maximilians-Universität München - München 80339, Germany, EU
Accepted: 17 January 2012
We have developed a novel method to evaluate the potential profile of a molecular motor at each chemical state from only the probe's trajectory and applied it to a rotary molecular motor F1-ATPase. By using this method, we could also obtain the information regarding the mechanochemical coupling and energetics. We demonstrate that the position-dependent transition of the chemical states is the key feature for the highly efficient free-energy transduction by F1-ATPase.
PACS: 05.70.Ln – Nonequilibrium and irreversible thermodynamics / 05.40.Jc – Brownian motion / 87.16.Nn – Motor proteins (myosin, kinesin dynein)
© EPLA, 2012