Broad-tailed force distributions and velocity ordering in a heterogeneous membrane model for collective cell migration
1 Department of Physics, Indian Institute of Technology - Bombay, Powai, Mumbai-400 076, India
2 Department of Civil Engineering, Indian Institute of Technology - Bombay, Powai, Mumbai-400 076, India
Received: 4 April 2012
Accepted: 14 June 2012
Correlated velocity patterns and associated large length-scale transmission of traction forces have been observed in collective live cell migration as a response to a “wound”. We argue that a simple physical model of a force-driven heterogeneous elastic membrane sliding over a viscous substrate can qualitatively explain a few experimentally observed facts: i) the growth of velocity ordering which spreads from the wound boundary to the interior; ii) the exponential tails of the traction force distributions; and iii) the swirling pattern of velocities in the interior of the tissue.
PACS: 87.18.Hf – Spatiotemporal pattern formation in cellular populations / 05.40.-a – Fluctuation phenomena, random processes, noise, and Brownian motion
© EPLA, 2012