| Issue |
EPL
Volume 109, Number 3, February 2015
|
|
|---|---|---|
| Article Number | 38002 | |
| Number of page(s) | 5 | |
| Section | Interdisciplinary Physics and Related Areas of Science and Technology | |
| DOI | https://doi.org/10.1209/0295-5075/109/38002 | |
| Published online | 12 February 2015 | |
Anomalous diffusion of DNA on a supported cationic lipid membrane
1 Institute of Physics, Academia Sinica - Taipei, Taiwan 11529
2 Department of Physics, National Central University - Jhongli, Taiwan 32001
(b) wtjuan@phys.sinica.edu.tw (corresponding author)
Received: 11 November 2014
Accepted: 21 January 2015
We used fluorescence microscopy to investigate the diffusion dynamics of individual DNA molecules on supported cationic lipid membranes. The mean-squared displacement of DNA on the membrane surface showed sub-diffusion associated with a slower DNA conformational relaxation at a short time scale. The evolution of contours of these non-entangled DNA at this short time scale was retained within a “hypothetical tube” of diameter 
. Inhomogeneous DNA-surface interaction along the DNA contour, identified by total internal reflection fluorescence microscopy, suggested a mechanism for the anomalous dynamics of DNA on the membrane.
PACS: 82.35.Gh – Polymers on surfaces; adhesion / 87.15.H- – Dynamics of biomolecules / 87.14.gk – DNA
© EPLA, 2015
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