| Issue |
EPL
Volume 115, Number 4, August 2016
|
|
|---|---|---|
| Article Number | 48001 | |
| Number of page(s) | 6 | |
| Section | Interdisciplinary Physics and Related Areas of Science and Technology | |
| DOI | https://doi.org/10.1209/0295-5075/115/48001 | |
| Published online | 20 September 2016 | |
Ionic characteristics in cardiac alternans suppression using T ± ϵ feedback control
1 Department of Physics and Center for Complex Systems, National Central University Taoyuan City, Taiwan 320, ROC
2 Electrical and Computer Systems Engineering, School of Engineering, Monash University 47500 Bandar Sunway, Malaysia
3 Institute of Physics, VAST - 10 Dao Tan, Ba Dinh, Hanoi, Vietnam
4 Institute of Physics, Academia Sinica - Nankang, Taipei, Taiwan 115, ROC
Received: 2 July 2016
Accepted: 26 August 2016
Using the Luo-Rudy I model, the recently proposed 
feedback control for suppressing cardiac alternans is investigated. It is shown that cardiac alternans, induced by fast pacing (of period T), can be dramatically reduced by small changes of fixed magnitude (ϵ) under feedback control when ϵ exceeds a critical threshold. Detail information on various ionic currents and cytosolic calcium concentration ![$\big([\text{Ca}]_{\text{i}}\big)$](/articles/epl/abs/2016/16/epl18081/epl18081_tex_eq2.png)
are examined when the cardiac cell is under control. In particular, the alternans in ionic currents and [Ca]i are also reduced under the control. Furthermore, when ϵ exceeds the threshold value, the average [Ca]i level is significantly higher when the alternans is under control, suggesting a possible physiological improvement of cardiac contractions.
PACS: 87.19.Hh – Cardiac dynamics / 05.45.-a – Nonlinear dynamics and chaos / 05.45.Gg – Control of chaos, applications of chaos
© EPLA, 2016
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