Issue |
Europhys. Lett.
Volume 55, Number 5, September 2001
|
|
---|---|---|
Page(s) | 746 - 752 | |
Section | Interdisciplinary physics and related areas of science and technology | |
DOI | https://doi.org/10.1209/epl/i2001-00477-3 | |
Published online | 01 December 2003 |
Hysteresis and bistability in a realistic model for
-driven
oscillations
1
Department of Medical Physics and Biophysics, University of
Nijmegen
Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
2
Departments of Biochemistry and Cell Physiology, University of Nijmegen
Geert Grooteplein Zuid 30, 6525 AD Nijmegen,
The Netherlands
Corresponding author: jtorres@onsager.ugr.es
Received:
17
November
2000
Accepted:
13
June
2001
We present a new model for inositol triphosphate -induced
cytosolic
oscillations in non-excitable cells. The model
includes the various
in- and efflux pathways reported to exist in these cells.
In particular, it features the complex regulation of the
release from the endoplasmic reticulum (ER) by
cytosolic
and
in the ER.
Bifurcation analysis revealed that the model accurately predicts the
cytosolic
dynamics in a typical non-excitable cell.
Diffusional coupling of this model in a two-dimensional
network shows hysteresis and bistability in its collective
dynamics. Depending on the strength of the diffusion constant, we find
traveling or spiral waves as solutions of this system.
PACS: 87.10.+e – General theory and mathematical aspects / 87.16.-b – Subcellular structure and processes / 87.16.Ac – Theory and modeling; computer simulation
© EDP Sciences, 2001
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