Volume 88, Number 2, October 2009
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||11 November 2009|
Pattern formation of glioma cells: Effects of adhesion
Department of Physics, Oakland University - Rochester, MI 48309, USA
2 Department of Physics and Michigan Center for Theoretical Physics, The University of Michigan Ann Arbor, MI 48109, USA
3 Department of Neurological Surgery, The Ohio State University Medical Center - Columbus, OH 43210, USA
Corresponding author: firstname.lastname@example.org
Accepted: 13 October 2009
We investigate clustering of malignant glioma cells. In vitro experiments in collagen gels identified a cell line that formed clusters in a region of low cell density, whereas a very similar cell line (which lacks an important mutation) did not cluster significantly. We hypothesize that the mutation affects the strength of cell-cell adhesion. We investigate this effect in a new experiment, which follows the clustering dynamics of glioma cells on a surface. We interpret our results in terms of a stochastic model and identify two mechanisms of clustering. First, there is a critical value of the strength of adhesion; above the threshold, large clusters grow from a homogeneous suspension of cells; below it, the system remains homogeneous, similarly to the ordinary phase separation. Second, when cells form a cluster, we have evidence that they increase their proliferation rate. We have successfully reproduced the experimental findings and found that both mechanisms are crucial for cluster formation and growth.
PACS: 87.18.Hf – Spatiotemporal pattern formation in cellular populations / 87.18.Gh – Cell-cell communication; collective behavior of motile cells / 87.10.Hk – Lattice models
© EPLA, 2009
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