Decoding of intracellular calcium spike trains
Department of Clinincal Endocrinology, Medical School Hannover,
Carl-Neuberg-Str. 1, D-30625, Hannover, Germany
Accepted: 23 February 1998
Cells respond to external signals, such as hormonal stimuli, by generating repetitive spikes in the intracellular free-calcium concentration . These spikes, which can be modulated in their frequency and amplitude, regulate diverse cellular processes. Experimentally, can be assessed continuously in contrast to cellular responses represented by the activation of proteins. We propose a mathematical model that allows for the on-line decoding of spike trains into cellular responses represented by the activation of proteins.
PACS: 07.05.Tp – Computer modeling and simulation / 87.22.-q – Physics of cellular and physiological processes / 89.70.+c – Information science
© EDP Sciences, 1998