On the helix-coil transition in grafted chains
UMR 5819, DRFMC/SI3M, CEA-Grenoble - 17, rue des Martyrs
38054 Grenoble Cedex 9, France
Accepted: 20 April 2000
The helix-coil transition is modified by grafting to a surface. This modification is studied for short peptides capable of forming α-helices. Three factors are involved: i) the grafting can induce change of the boundary free energy of the helical domain ii) the van der Waals attraction between the helices and iii) the crowding-induced stretching of the coils. As a result, the helix-coil transition acquires “all or nothing” characteristics. In addition the transition temperature is elevated and the transition itself sharpens as the grafting density increases.
PACS: 61.25.Hq – Macromolecular and polymer solutions; polymer melts; swelling / 87.15.-v – Biomolecules: structure and physical properties / 87.15.He – Dynamics and conformational changes
© EDP Sciences, 2000