Europhys. Lett., 56 (4) , pp. 603-609 (2001)
Detachment of molecular motors under tangential loadingA. Parmeggiani1, 2, 3, F. Jülicher1, L. Peliti4 and J. Prost1
1 Institut Curie, Physico-Chimie Curie, UMR 168 CNRS/IC 26 rue d'Ulm, F-75248 Paris Cedex 05, France
2 Institut für Theoretische Physik, T34, Physik Department, TU-München James-Franck-Straße, D-85747 Garching, Germany
3 Lyman Laboratory of Physics, Harvard University - Cambridge MA 02138, USA
4 Dipartimento di Scienze Fisiche and Unità INFM, Università "Federico II" Complesso Monte S. Angelo, I-80126 Napoli, Italy
(Received 5 March 2001; accepted in final form 22 August 2001)
We introduce a general framework to study the processivity of molecular motors moving along a polar filament and discuss the average time spent attached to the filament as a function of a tangentially applied load. Our study of specific models suggests that the attachment time of a motor decreases with increasing ATP concentration and that double-headed motors such as kinesins lose their processivity under forcing conditions while processive single-headed motors are less sensitive to tangential forcing.
87.16.Nn - Motor proteins.
87.10.+e - General theory and mathematical aspects.
05.40.-a - Fluctuation phenomena, random processes, noise, and Brownian motion.
© EDP Sciences 2001