Simulation of the growth of neurospheresV. P. Zhdanov1, 2 and B. Kasemo1
1 Department of Applied Physics, Chalmers University of Technology S-412 96 Göteborg, Sweden
2 Boreskov Institute of Catalysis, Russian Academy of Sciences Novosibirsk 630090, Russia
received 13 May 2004; accepted in final form 30 July 2004
Under appropriate conditions, the neural stem cells are able to proliferate and to form suspended neurospheres containing stem cells and neuronal and glial progenitors in different stages of differentiation. Our lattice Monte Carlo simulations, taking into account the effect of spatial constraints and cell-cell adhesion on cell diffusion and division, show that i) the neurosphere-size distribution is very broad and ii) the spatial distribution of various cells inside neurospheres is heterogeneous.
87.18.Hf - Spatiotemporal pattern formation in cellular populations.
05.40.-a - Fluctuation phenomena, random processes, noise, and Brownian motion.
© EDP Sciences 2004