Peptide-size-dependent active transport in the proteasomeA. Zaikin1, 2 and T. Pöschel1
1 Humboldt Universität zu Berlin, Charité, Institut für Biochemie Monbijoustraße 2, D-10117 Berlin, Germany
2 Department of Mathematical Sciences, University of Exeter - EX4 4QE Exeter, UK
received 8 September 2004; accepted in final form 11 January 2005
published online 9 February 2005
We investigate the transport of proteins inside the proteasome and propose an active-transport mechanism based on a spatially asymmetric interaction potential of peptide chains. The transport is driven by fluctuations which are always present in such systems. We compute the peptide-size-dependent transport rate which is essential for the functioning of the proteasome. In agreement with recent experiments, varying temperature changes the transport mechanism qualitatively.
05.40.-a - Fluctuation phenomena, random processes, noise, and Brownian motion.
05.40.Ca - Noise.
05.60.-k - Transport processes.
© EDP Sciences 2005