Europhys. Lett.
Volume 72, Number 2, October 2005
Page(s) 301 - 307
Section Interdisciplinary physics and related areas of science and technology
Published online 14 September 2005
Europhys. Lett., 72 (2), pp. 301-307 (2005)
DOI: 10.1209/epl/i2005-10225-9

Four-states phase diagram of proteins

O. Collet

Équipe de Dynamique des Assemblages Membranaires, UMR CNRS 7565 Faculté des Sciences, Université Henri Poincaré-Nancy 1 54506 Vandoeuvre-lès-Nancy, France

received 19 April 2005; accepted in final form 16 August 2005
published online 14 September 2005

A four-states phase diagram for protein folding as a function of temperature and solvent quality is derived from an improved 2d lattice model taking into account the temperature dependence of the hydrophobic effect. The phase diagram exhibits native, globule and two coil-type regions. In agreement with experiment, the model reproduces the phase transitions indicative of both warm and cold denaturations. Finally, it predicts transitions between the two coil states and a critical point.

87.14.Ee - Proteins.
64.70.-p - Specific phase transitions.
87.15.Aa - Theory and modeling; computer simulation.

© EDP Sciences 2005