Europhys. Lett.
Volume 74, Number 3, May 2006
Page(s) 547 - 553
Section Interdisciplinary physics and related areas of science and technology
Published online 31 March 2006
Europhys. Lett., 74 (3), pp. 547-553 (2006)
DOI: 10.1209/epl/i2005-10560-9

Long-range transport and universality classes in in vitro viral infection spread

S. C. Manrubia1, J. García-Arriaza2, E. Domingo1, 2 and C. Escarmís2

1  Centro de Astrobiología, CSIC-INTA - Ctra. de Ajalvir km. 4 28850 Torrejón de Ardoz, Madrid, Spain
2  Centro de Biología Molecular Severo Ochoa, CSIC-UAM - Universidad Autónoma de Madrid - Cantoblanco, 28049 Madrid, Spain

received 3 November 2005; accepted in final form 8 March 2006
published online 31 March 2006

Dispersal mechanisms play a main role in the dynamics of infection spread. Recent experimental results with in vitro infections of foot-and-mouth disease virus reveal that the time needed for the virus to kill a cellular monolayer depends qualitatively on the number of viral particles required to initiate infection in a susceptible cell. A two-dimensional susceptible-infected-removed (SIR) model based on the experimental setting agrees with the observations only when viral particles are subject to long-range transport. Numerical and analytical results show that this long-range transport plays a role when a single particle causes infection, while it is inefficient when complementation between two or more particles is necessary.

87.15.Aa - Theory and modeling; computer simulation.
87.23.-n - Ecology and evolution.
89.90.+n - Other topics in areas of applied and interdisciplinary physics.

© EDP Sciences 2006