Issue
Europhys. Lett.
Volume 76, Number 4, November 2006
Page(s) 616 - 622
Section Condensed matter: structural, mechanical and thermal properties
DOI http://dx.doi.org/10.1209/epl/i2006-10302-7
Published online 25 October 2006
Europhys. Lett., 76 (4), pp. 616-622 (2006)
DOI: 10.1209/epl/i2006-10302-7

DNA-origami technique for olympic gels

G. T. Pickett

College of Natural Sciences and Mathematics, California State University Long Beach Long Beach, CA 90840, USA


received 20 July 2006; accepted 18 September 2006
published online 25 October 2006

Abstract
Taking advantage of the specific base-pairing interaction of DNA, I propose a robust method for creating melt topological or "olympic" gels. Flexible polymers which have been end-decorated with complimentary base-pair sequences will undergo end-closing reactions with either themselves (forming loops) or with neighboring chains (creating linear, but lengthened chains). The loop-forming or chain-forming process can be controlled by how many distinct ligand pairs occur in the system. A gel formed of these interlocking rings will display a sensitivity to dissolve when brought into contact with a large concentration of DNA fragments, thus giving a biologically-specific trigger for drug delivery by olympic microgels.

PACS
61.82.Pv - Polymers, organic compounds.
81.16.Fg - Supramolecular and biochemical assembly.
87.14.Gg - DNA, RNA.

© EDP Sciences 2006