DNA-origami technique for olympic gelsG. T. Pickett
College of Natural Sciences and Mathematics, California State University Long Beach Long Beach, CA 90840, USA
received 20 July 2006; accepted 18 September 2006
published online 25 October 2006
Taking advantage of the specific base-pairing interaction of DNA, I propose a robust method for creating melt topological or "olympic" gels. Flexible polymers which have been end-decorated with complimentary base-pair sequences will undergo end-closing reactions with either themselves (forming loops) or with neighboring chains (creating linear, but lengthened chains). The loop-forming or chain-forming process can be controlled by how many distinct ligand pairs occur in the system. A gel formed of these interlocking rings will display a sensitivity to dissolve when brought into contact with a large concentration of DNA fragments, thus giving a biologically-specific trigger for drug delivery by olympic microgels.
61.82.Pv - Polymers, organic compounds.
81.16.Fg - Supramolecular and biochemical assembly.
87.14.Gg - DNA, RNA.
© EDP Sciences 2006