Issue
EPL
Volume 77, Number 4, February 2007
Article Number 48001
Number of page(s) 6
Section Interdisciplinary Physics and Related Areas of Science and Technology
DOI http://dx.doi.org/10.1209/0295-5075/77/48001
Published online 25 January 2007
EPL, 77 (2007) 48001
DOI: 10.1209/0295-5075/77/48001

Bubble coalescence in breathing DNA: Two vicious walkers in opposite potentials

T. Novotný1, 2, J. N. Pedersen3, T. Ambjörnsson4, 5, M. S. Hansen6 and R. Metzler4, 7

1  Nano-Science Center, University of Copenhagen - Universitetsparken 5, 2100 Copenhagen, Denmark
2  Department of Condensed Matter Physics, Faculty of Mathematics and Physics, Charles University - Ke Karlovu 5, 121 16 Prague, Czech Republic
3  Mathematical Physics, Lund University - Box 118, 22100 Lund, Sweden
4  Nordic Institute for Theoretical Physics (NORDITA) - Blegdamsvej 17, 2100 Copenhagen, Denmark
5  Department of Chemistry, Massachusetts Institute of Technology - 77 Massachusetts Avenue, Cambridge, MA 02139, USA
6  Department of Mathematics, Technical University of Denmark - Bldg. 303S, Matematiktorvet, 2800 Kgs. Lyngby, Denmark
7  Physics Department, University of Ottawa - 150 Louis Pasteur, Ottawa, ON, K1N 6N5, Canada


received 27 October 2006; accepted in final form 12 December 2006; published February 2007
published online 25 January 2007

Abstract
We investigate the coalescence of two DNA bubbles initially located at weak segments and separated by a more stable barrier region in a designed construct of double-stranded DNA. The characteristic time for bubble coalescence and the corresponding distribution are derived, as well as the distribution of coalescence positions along the barrier. Below the melting temperature, we find a Kramers-type barrier crossing behaviour, while at high temperatures, the bubble corners perform drift-diffusion towards coalescence. The results are obtained by mapping the bubble dynamics on the problem of two vicious walkers in opposite potentials.

PACS
87.14.Gg - DNA, RNA.
02.50.Ey - Stochastic processes.
82.37.-j - Single molecule kinetics.

© Europhysics Letters Association 2007