Close contact fluctuations: The seeding of signalling domains in the immunological synapseAmit K. Chattopadhyay and Nigel J. Burroughs
Mathematics Institute, University of Warwick - Coventry CV4 7AL, UK
received 22 August 2006; accepted in final form 12 December 2006; published February 2007
published online 5 February 2007
We analyse the size and density of thermally induced regions of close contact in cell : cell contact interfaces within a harmonic potential approximation, estimating these regions to be below one-tenth of a micron across. Our calculations indicate that as the distance between the close contact threshold depth and the mean membrane-membrane separation increases, the density of close contact patches decreases exponentially while there is only a minimal variation in their mean size. The technique developed can be used to calculate the probability of first crossing in reflection symmetry violating systems.
87.16.Dg - Membranes, bilayers, and vesicles.
05.40.-a - Fluctuation phenomena, random processes, noise, and Brownian motion.
87.10.+e - General theory and mathematical aspects.
© Europhysics Letters Association 2007