Theory of the length distribution of tread-milling actin filaments inside bundlesN. S. Gov
Department of Chemical Physics, The Weizmann Institute of Science - P.O.B. 26, Rehovot, Israel 76100
received 11 July 2006; accepted in final form 26 January 2007; published March 2007
published online 6 March 2007
The length distribution of tread-milling actin filaments has been measured in vitro, in the presence of severing and cross-linking proteins. The cross-linking proteins induce the formation of bundles, and we present here a kinetic model for this system which takes into account the inherent asymmetry and non-equilibrium nature of the tread-milling actin filaments. The effects of actin cross-linkers is to make the length distribution of filaments inside bundles narrower compared to free filaments. We get good agreement with the available experimental data.
87.16.Ka - Filaments, microtubules, their networks, and supramolecular assemblies.
87.15.Nn - Properties of solutions; aggregation and crystallization of macromolecules.
© Europhysics Letters Association 2007