Issue
EPL
Volume 77, Number 6, March 2007
Article Number 68005
Number of page(s) 6
Section Interdisciplinary Physics and Related Areas of Science and Technology
DOI http://dx.doi.org/10.1209/0295-5075/77/68005
Published online 06 March 2007
EPL, 77 (2007) 68005
DOI: 10.1209/0295-5075/77/68005

Theory of the length distribution of tread-milling actin filaments inside bundles

N. S. Gov

Department of Chemical Physics, The Weizmann Institute of Science - P.O.B. 26, Rehovot, Israel 76100


received 11 July 2006; accepted in final form 26 January 2007; published March 2007
published online 6 March 2007

Abstract
The length distribution of tread-milling actin filaments has been measured in vitro, in the presence of severing and cross-linking proteins. The cross-linking proteins induce the formation of bundles, and we present here a kinetic model for this system which takes into account the inherent asymmetry and non-equilibrium nature of the tread-milling actin filaments. The effects of actin cross-linkers is to make the length distribution of filaments inside bundles narrower compared to free filaments. We get good agreement with the available experimental data.

PACS
87.16.Ka - Filaments, microtubules, their networks, and supramolecular assemblies.
87.15.Nn - Properties of solutions; aggregation and crystallization of macromolecules.

© Europhysics Letters Association 2007