Numerical study of IP3-dependent Ca2+ spiral waves in Xenopus oocytesJun Tang1, 2, Ya Jia1, Jun Ma1, 3 and Ming Yi1
1 Department of Physics and Institute of Biophysics, Huazhong Normal University - Wuhan 430079, China
2 College of Science, China University of Mining and Technology - Xuzhou 221008, China
3 Department of Physics, Lanzhou University of Technology - Lanzhou 730050 China
received 16 May 2008; accepted in final form 29 July 2008; published September 2008
published online 10 September 2008
Based on a spatial extended Tang-Othmer Ca2+ model, intracellular Ca2+ spiral waves in Xenopus oocytes are numerically studied. Results show that the spiral dynamics depends on the concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP3). Varying the IP3 concentration, the spiral dynamics undergoes transitions from rigidly rotating spiral waves to meandering ones, even the spiral waves cannot exist in the system for large or little enough IP3 concentration. Understanding the dependence of spiral dynamics on IP3 concentration provides us theoretical clue to control the spiral waves through changing the IP3 concentration in experiments.
87.10.Ed - Biological and medical physics: Ordinary differential equations (ODE), partial differential equations (PDE), integrodifferential models.
82.40.Ck - Pattern formation in reactions with diffusion, flow and heat transfer.
87.17.Aa - Modeling, computer simulation of cell processes.
© EPLA 2008