The fate of a polymer nanoparticle subject to flow-induced shear stressesG. A. Buxton
Department of Physics, Case Western Reserve University - Cleveland, OH 44106, USA
received 30 July 2008; accepted in final form 15 September 2008; published October 2008
published online 14 October 2008
Polymer nanoparticles are used for the targeted delivery of drugs, where their mechanical response to hydrodynamic flows can influence their performance. In this study, computer simulations elucidate the deformation of a polymer nanoparticle in a fluid under shear. It is found that hydrodynamic stresses can significantly deform polymer nanoparticles, with the particle becoming both stretched and squeezed (potentially expressing, or wringing out, an encapsulated fluid), and that the porous nature of polymer networks can allow fluid flow through the nanoparticle (potentially facilitating the release of an encapsulated drug). The use of computer simulations, therefore, which can capture the interactions between the mechanics of a polymer nanoparticle and the fluid dynamics of blood flow will play a significant role in developing and optimising polymer nanoparticle drug delivery systems.
62.25.-g - Mechanical properties of nanoscale systems.
83.80.Hj - Material type: Suspensions, dispersions, pastes, slurries, colloids.
87.10.Hk - Biological and medical physics: Lattice models.
© EPLA 2008