Issue
EPL
Volume 84, Number 5, December 2008
Article Number 58009
Number of page(s) 6
Section Interdisciplinary Physics and Related Areas of Science and Technology
DOI http://dx.doi.org/10.1209/0295-5075/84/58009
Published online 12 December 2008
EPL, 84 (2008) 58009
DOI: 10.1209/0295-5075/84/58009

Collective vesicle transport on biofilaments carried by competing molecular motors

S. Muhuri and I. Pagonabarraga

Departament de Fisica Fonamental, Universitat de Barcelona - Carrer Martí i Franqués 1, 08028-Barcelona, Spain, EU

ipagonabarraga@ub.edu

received 21 July 2008; accepted in final form 3 November 2008; published December 2008
published online 12 December 2008

Abstract
We study a minimal model for bidirectional collective transport of cargo vesicles on a biofilament where the competing motion is characterized by the cargo densities moving toward the opposite filament ends. The model incorporates inter-vesicle interaction (through excluded volume) and active transport as well as motor regulation and environment interactions. From the current profiles we derive the non-equilibrium phase diagram. In terms of the filament end cargo fluxes, the phase diagram allows for re-emergent density shocks. This approach captures qualitatively a number of features of the collective state of the cargoes associated with bidirectional transport: current reversals due to internal regulation, boundary induced phase transitions and domain wall localization in the bulk. Vesicle polarization emerges naturally within the proposed framework.

PACS
87.10.-e - General theory and mathematical aspects.
87.16.A- - Theory, modeling, and simulations.
87.16.Nn - Motor proteins (myosin, kinesin dynein).

© EPLA 2008