Collective vesicle transport on biofilaments carried by competing molecular motorsS. Muhuri and I. Pagonabarraga
Departament de Fisica Fonamental, Universitat de Barcelona - Carrer Martí i Franqués 1, 08028-Barcelona, Spain, EU
received 21 July 2008; accepted in final form 3 November 2008; published December 2008
published online 12 December 2008
We study a minimal model for bidirectional collective transport of cargo vesicles on a biofilament where the competing motion is characterized by the cargo densities moving toward the opposite filament ends. The model incorporates inter-vesicle interaction (through excluded volume) and active transport as well as motor regulation and environment interactions. From the current profiles we derive the non-equilibrium phase diagram. In terms of the filament end cargo fluxes, the phase diagram allows for re-emergent density shocks. This approach captures qualitatively a number of features of the collective state of the cargoes associated with bidirectional transport: current reversals due to internal regulation, boundary induced phase transitions and domain wall localization in the bulk. Vesicle polarization emerges naturally within the proposed framework.
87.10.-e - General theory and mathematical aspects.
87.16.A- - Theory, modeling, and simulations.
87.16.Nn - Motor proteins (myosin, kinesin dynein).
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