Issue
EPL
Volume 88, Number 4, November 2009
Article Number 48004
Number of page(s) 6
Section Interdisciplinary Physics and Related Areas of Science and Technology
DOI http://dx.doi.org/10.1209/0295-5075/88/48004
Published online 03 December 2009
EPL, 88 (2009) 48004
DOI: 10.1209/0295-5075/88/48004

Adaptive gene regulatory networks

F. Stauffer1 and J. Berg1, 2

1   Institut für Theoretische Physik, Universität zu Köln - Zülpicher Straße 77, 50937 Köln, Germany, EU
2   Physikalisches Institut, Albert-Ludwigs-Universität Freiburg - Herrmann Herder-Str. 3, 79104 Freiburg, Germany, EU

berg@thp.uni-koeln.de

received 8 April 2009; accepted in final form 5 November 2009; published November 2009
published online 3 December 2009

Abstract
Regulatory interactions between genes show a large amount of cross-species variability, even when the underlying functions are conserved: there are many ways to achieve the same function. Here we investigate the ability of regulatory networks to reproduce given expression levels within a simple model of gene regulation. We find an exponentially large space of regulatory networks compatible with a given set of expression levels, giving rise to an extensive entropy of networks. Typical realisations of regulatory networks are found to share a bias towards symmetric interactions, in line with empirical evidence.

PACS
87.16.Yc - Regulatory genetic and chemical networks.
87.23.Kg - Dynamics of evolution.
87.18.Sn - Neural networks and synaptic communication.

© EPLA 2009