Triggering up states in all-to-all coupled neurons
Institute for Neuro- and Bioinformatics, University of Lübeck - 23538 Lübeck, Germany, EU
2 Graduate School for Computing in Medicine and Life Science, University of Lübeck - 23538 Lübeck, Germany, EU
3 Institute for Theoretical Physics and Astrophysics, University of Kiel - 24098 Kiel, Germany, EU
Accepted: 9 March 2010
Slow-wave sleep in mammalians is characterized by a change of large-scale cortical activity currently paraphrased as cortical Up/Down states. A recent experiment demonstrated a bistable collective behaviour in ferret slices, with the remarkable property that the Up states can be switched on and off with pulses, or excitations, of same polarity; whereby the effect of the second pulse significantly depends on the time interval between the pulses. Here we present a simple time-discrete model of a neural network that exhibits this type of behaviour, as well as quantitatively reproduces the time dependence found in the experiments.
PACS: 87.19.lj – Neuronal network dynamics / 87.19.lm – Synchronization in the nervous system / 87.18.Sn – Neural networks and synaptic communication
© EPLA, 2010