Creating morphable logic gates using logical stochastic resonance in an engineered gene network
School of Biological and Health Systems Engineering, Arizona State University - Tempe, AZ 85287-9709, USA
2 School of Electrical, Computer and Energy Engineering, Arizona State University - Tempe, AZ 85287-5706, USA
3 SPAWAR Systems Center Pacific - San Diego, CA 92152-5001, USA
Accepted: 22 December 2010
The idea of Logical Stochastic Resonance is adapted and applied to an autoregulatory gene network in the bacteriophage λ. This biological logic gate can emulate or morph the AND and OR gates, through varying internal system parameters, in a noisy background. Such logic gates afford intriguing possibilities in the realization of engineered genetic networks, in which the function of the gate can be changed after the network has been assembled: this allows a single gene network to be used for many different applications in the emerging field of synthetic biology.
PACS: 87.16.Yc – Regulatory genetic and chemical networks / 87.18.Cf – Genetic switches and networks / 87.18.-h – Biological complexity
© EPLA, 2011