| Issue |
Europhys. Lett.
Volume 42, Number 2, April II 1998
|
|
|---|---|---|
| Page(s) | 143 - 148 | |
| Section | General | |
| DOI | https://doi.org/10.1209/epl/i1998-00220-2 | |
| Published online | 01 September 2002 | |
Decoding of intracellular calcium spike trains
Department of Clinincal Endocrinology, Medical School Hannover,
Carl-Neuberg-Str. 1, D-30625, Hannover, Germany
Received:
5
December
1997
Accepted:
23
February
1998
Cells respond to external signals, such as hormonal stimuli, by generating
repetitive spikes in the intracellular free-calcium concentration
. These 
spikes, which can be modulated in
their frequency and amplitude, regulate diverse cellular processes.
Experimentally, can be assessed continuously in contrast
to cellular responses represented by the activation of proteins.
We propose a mathematical model that allows for the on-line decoding of
spike trains into cellular responses represented by the
activation of proteins.
PACS: 07.05.Tp – Computer modeling and simulation / 87.22.-q – Physics of cellular and physiological processes / 89.70.+c – Information science
© EDP Sciences, 1998
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