| Issue |
Europhys. Lett.
Volume 49, Number 2, January II 2000
|
|
|---|---|---|
| Page(s) | 169 - 175 | |
| Section | General | |
| DOI | https://doi.org/10.1209/epl/i2000-00128-3 | |
| Published online | 01 September 2002 | |
The role of the energy gap in protein folding dynamics
Service de Physique Théorique,
Centre d'Etudes de Saclay CEA, 91191 Gif-sur-Yvette,
France
Corresponding author: pitard@spht.saclay.cea.fr
Received:
16
November
1998
Accepted:
3
November
1999
The dynamics of folding of proteins is studied by means of a phenomenological master equation. The energy distribution is taken as a truncated exponential for the misfolded states plus a native state sitting below the continuum. The influence of the gap on the dynamics is studied, for various models of the transition probabilities between the different states of the protein. We show that for certain models, the relaxation to the native state is accelerated by increasing the gap, whereas for others it is slowed down.
PACS: 05.40.-a – Fluctuation phenomena, random processes, noise, and Brownian motion / 05.70.Ln – Nonequilibrium and irreversible thermodynamics / 05.90.+m – Other topics in statistical physics, thermodynamics, and nonlinear dynamical systems
© EDP Sciences, 2000
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