| Issue |
Europhys. Lett.
Volume 54, Number 6, June II 2001
|
|
|---|---|---|
| Page(s) | 826 - 832 | |
| Section | Interdisciplinary physics and related areas of science and technology | |
| DOI | https://doi.org/10.1209/epl/i2001-00328-9 | |
| Published online | 01 December 2003 | |
First-order transition between adhesion states in a system mimicking cell-tissue interaction
Lehrstuhl für Experimentalphysik (Biophysik) E22, Technische Universität München
James-Franck-St., D-85747 Garching bei München, Germany
Corresponding author: aboulbit@physik.tu-muenchen.de
Received:
28
November
2000
Accepted:
2
April
2001
We establish a model of cell-tissue interaction consisting of vesicles
carrying lipopolymers (to mimic the glycocalix) and mobile specific ligands
of the blood platelet integrin 
covering the
substrate. We find the phase diagram with a first-order transition between
a gravity-controlled weak state of the vesicle-substrate adhesion and a
strong-adhesion state governed by receptor-ligand interaction. Adhesion
energy 
is measured as a function of ligand and
repeller concentration by interferometric contour analysis on the basis of a
new refined model of soft shell adhesion (accounting for the membrane bending
and stretching at the adhesion rim of the ellipsoidal vesicle). At ligand
densities comparable to integrin density,
decreases sharply. Increasing the repeller content weakens the adhesion
strength.
PACS: 87.16.Dg – Membranes, bilayers, and vesicles / 87.15.Kg – Molecular interactions; membrane-protein interactions / 46.70.De – Beams, plates and shells
© EDP Sciences, 2001
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