Issue |
Europhys. Lett.
Volume 56, Number 4, November 2001
|
|
---|---|---|
Page(s) | 603 - 609 | |
Section | Interdisciplinary physics and related areas of science and technology | |
DOI | https://doi.org/10.1209/epl/i2001-00563-6 | |
Published online | 01 December 2003 |
Detachment of molecular motors under tangential loading
1
Institut Curie, Physico-Chimie Curie, UMR 168
CNRS/IC
26 rue d'Ulm,
F-75248 Paris Cedex 05, France
2
Institut für
Theoretische Physik, T34, Physik
Department, TU-München
James-Franck-Straße, D-85747 Garching, Germany
3
Lyman Laboratory of Physics,
Harvard University -
Cambridge MA 02138,
USA
4
Dipartimento
di Scienze Fisiche and Unità INFM,
Università "Federico II" Complesso
Monte S. Angelo, I-80126
Napoli, Italy
Received:
5
March
2001
Accepted:
22
August
2001
We introduce a general framework to study the processivity of molecular motors moving along a polar filament and discuss the average time spent attached to the filament as a function of a tangentially applied load. Our study of specific models suggests that the attachment time of a motor decreases with increasing ATP concentration and that double-headed motors such as kinesins lose their processivity under forcing conditions while processive single-headed motors are less sensitive to tangential forcing.
PACS: 87.16.Nn – Motor proteins / 87.10.+e – General theory and mathematical aspects / 05.40.-a – Fluctuation phenomena, random processes, noise, and Brownian motion
© EDP Sciences, 2001
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