Volume 56, Number 4, November 2001
|Page(s)||603 - 609|
|Section||Interdisciplinary physics and related areas of science and technology|
|Published online||01 December 2003|
Detachment of molecular motors under tangential loading
Institut Curie, Physico-Chimie Curie, UMR 168
26 rue d'Ulm,
F-75248 Paris Cedex 05, France
2 Institut für Theoretische Physik, T34, Physik Department, TU-München James-Franck-Straße, D-85747 Garching, Germany
3 Lyman Laboratory of Physics, Harvard University - Cambridge MA 02138, USA
4 Dipartimento di Scienze Fisiche and Unità INFM, Università "Federico II" Complesso Monte S. Angelo, I-80126 Napoli, Italy
Accepted: 22 August 2001
We introduce a general framework to study the processivity of molecular motors moving along a polar filament and discuss the average time spent attached to the filament as a function of a tangentially applied load. Our study of specific models suggests that the attachment time of a motor decreases with increasing ATP concentration and that double-headed motors such as kinesins lose their processivity under forcing conditions while processive single-headed motors are less sensitive to tangential forcing.
PACS: 87.16.Nn – Motor proteins / 87.10.+e – General theory and mathematical aspects / 05.40.-a – Fluctuation phenomena, random processes, noise, and Brownian motion
© EDP Sciences, 2001
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