Volume 59, Number 6, September II 2002
|Page(s)||903 - 909|
|Section||Interdisciplinary physics and relates areas of science and technology|
|Published online||01 September 2002|
Phases of the secondary structures of RNA sequences
Department of Physics, UC San Diego-La Jolla, CA 92093-0319, USA
2 Physics Department, The Ohio State University - Columbus, OH 43210-1106, USA
Accepted: 21 June 2002
Formation of RNA secondary structures is an example of the sequence-structure problem omnipresent in molecular biophysics. A basic theoretical issue concerns the phase behaviour of self-attracting random RNA sequences. By studying a simplified toy model of RNA folding, we show that there are two distinct possible phases for the random RNA below its melting transition —a molten phase in which an exponentially large number of allowed secondary structures have comparable free energies and coexist in thermal equilibrium, and a glass phase in which the equilibrium ensemble is dominated by one or a few structures with much lower free energies.
PACS: 87.15.Aa – Biomolecules: Theory and modeling; computer simulation / 05.40.-a – Fluctuation phenomena, random processes, noise, and Brownian motion / 87.15.Cc – Biomolecules: Folding and sequence analysis
© EDP Sciences, 2002
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