Volume 63, Number 6, September 2003
|Page(s)||908 - 914|
|Section||Interdisciplinary physics and related areas of science and technology|
|Published online||01 November 2003|
Individual chromosomes as viscoelastic copolymers
Laboratoire de Spectrométrie Physique, UMR 5588, Université Joseph Fourier Saint-Martin, d'Hères, France
2 Institut Albert Bonniot, Unité INSERM 309 - La Tronche, France
3 Cold Spring Harbor Laboratory - Cold Spring Harbor, NY, USA
Corresponding author: firstname.lastname@example.org
Accepted: 11 July 2003
We report elastic measurements of individual chromosomes observed in vitro. Free fluctuations of shapes show that a chromosome can be seen as a copolymer, exhibiting rigid regions alternating with semi-flexible regions. We characterize this behavior and compare it with known biopolymers. We further show that the inner part of a chromosome exhibits viscoelasticity, as extracted by the loading rate dependence of the stretch modulus. Taken together, these data suggest an organization for the chromosome as a copolymer composed of an inner rigid core exhibiting viscoelasticity surrounded by an elastic soft envelope.
PACS: 87.15.-v – Biomolecules: structure and physical properties / 82.35.Lr – Physical properties of polymers / 83.60.Bc – Linear viscoelasticity
© EDP Sciences, 2003
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.