Volume 65, Number 4, February 2004
|Page(s)||574 - 580|
|Section||Interdisciplinary physics and related areas of science and technology|
|Published online||01 February 2004|
Helicase activity on DNA as a propagating front
Institute of Physics - Bhubaneswar 751 005, India
Corresponding author: email@example.com
Accepted: 27 November 2003
We develop a propagating-front analysis, in terms of a local probability of zipping, for the helicase activity of opening up a double-stranded DNA (dsDNA). In a fixed-distance ensemble (conjugate to the fixed-force ensemble), the front separates the zipped and unzipped phases of a dsDNA and a drive acts locally around the front. Bounds from variational analysis and numerical estimates for the speed of a helicase are obtained. Different types of helicase behaviours can be distinguished by the nature of the drive.
PACS: 87.14.Gg – DNA, RNA / 87.15.He – Dynamics and conformational changes / 82.37.Rs – Single molecule manipulation of proteins and other biological molecules
© EDP Sciences, 2004
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