Volume 68, Number 5, December 2004
|Page(s)||746 - 752|
|Section||Interdisciplinary physics and related areas of science and technology|
|Published online||05 November 2004|
Periodically driven stochastic un- and refolding transitions of biopolymers
II. Institut für Theoretische Physik, Universität Stuttgart - 70550 Stuttgart, Germany
Accepted: 12 October 2004
Mechanical single-molecule experiments probe the energy profile of biomolecules. We show that in the case of a profile with two minima (like folded/unfolded), periodic driving leads to a stochastic resonance-like phenomenon. We demonstrate that the analysis of such data can be used to extract four basic parameters of such a transition and discuss the statistical requirements of the data acquisition. As advantages of the proposed scheme, a polymeric linker is explicitly included and thermal fluctuations within each well need not be resolved.
PACS: 87.15.-v – Biomolecules: structure and physical properties / 87.64.Dz – Scanning tunneling and atomic force microscopy
© EDP Sciences, 2004
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