| Issue |
Europhys. Lett.
Volume 69, Number 4, February 2005
|
|
|---|---|---|
| Page(s) | 643 - 649 | |
| Section | Interdisciplinary physics and related areas of science and technology | |
| DOI | https://doi.org/10.1209/epl/i2004-10390-3 | |
| Published online | 19 January 2005 | |
Work probability distribution in single-molecule experiments
Dipartimento di Scienze Fisiche and Unità INFM, Università “Federico II” Complesso Universitario di Monte S. Angelo, I-80126 Napoli, Italy
Corresponding author: imparato@na.infn.it
Received:
7
October
2004
Accepted:
13
December
2004
We derive and solve a differential equation satisfied by the probability distribution of the work done on a single biomolecule in a mechanical unzipping experiment. The unzipping is described as a thermally activated escape process in an energy landscape. The Jarzynski equality is recovered as an identity, independent of the pulling protocol. This approach allows one to easily evaluate, by numerical integration, the work distribution, once a few parameters of the energy landscape are known.
PACS: 87.14.Gg – DNA, RNA / 82.37.-j – Single molecule kinetics / 82.37.Rs – Single molecule manipulation of proteins and other biological molecules
© EDP Sciences, 2005
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