Volume 69, Number 5, March 2005
|Page(s)||725 - 731|
|Published online||09 February 2005|
Peptide-size–dependent active transport in the proteasome
Humboldt Universität zu Berlin, Charité, Institut für Biochemie Monbijoustraße 2, D-10117 Berlin, Germany
2 Department of Mathematical Sciences, University of Exeter - EX4 4QE Exeter, UK
Accepted: 11 January 2005
We investigate the transport of proteins inside the proteasome and propose an active-transport mechanism based on a spatially asymmetric interaction potential of peptide chains. The transport is driven by fluctuations which are always present in such systems. We compute the peptide-size–dependent transport rate which is essential for the functioning of the proteasome. In agreement with recent experiments, varying temperature changes the transport mechanism qualitatively.
PACS: 05.40.-a – Fluctuation phenomena, random processes, noise, and Brownian motion / 05.40.Ca – Noise / 05.60.-k – Transport processes
© EDP Sciences, 2005
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