Volume 72, Number 2, October 2005
|Page(s)||301 - 307|
|Section||Interdisciplinary physics and related areas of science and technology|
|Published online||14 September 2005|
Four-states phase diagram of proteins
Équipe de Dynamique des Assemblages Membranaires, UMR CNRS 7565 Faculté des Sciences, Université Henri Poincaré-Nancy 1 54506 Vandoeuvre-lès-Nancy, France
Accepted: 16 August 2005
A four-states phase diagram for protein folding as a function of temperature and solvent quality is derived from an improved 2d lattice model taking into account the temperature dependence of the hydrophobic effect. The phase diagram exhibits native, globule and two coil-type regions. In agreement with experiment, the model reproduces the phase transitions indicative of both warm and cold denaturations. Finally, it predicts transitions between the two coil states and a critical point.
PACS: 87.14.Ee – Proteins / 64.70.-p – Specific phase transitions / 87.15.Aa – Theory and modeling; computer simulation
© EDP Sciences, 2005
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