| Issue |
EPL
Volume 77, Number 4, February 2007
|
|
|---|---|---|
| Article Number | 48004 | |
| Number of page(s) | 5 | |
| Section | Interdisciplinary Physics and Related Areas of Science and Technology | |
| DOI | https://doi.org/10.1209/0295-5075/77/48004 | |
| Published online | 09 February 2007 | |
Modeling equilibrium clusters in lysozyme solutions
1
Department of Physics, University of Fribourg - CH-1700 Fribourg, Switzerland
2
Dipartimento di Fisica and CNR-INFM-SOFT, Università di Roma La Sapienza - Rome, Italy
Received:
15
November
2006
Accepted:
19
December
2006
We present a combined experimental and numerical study of the equilibrium cluster formation in globular-protein solutions under no-added salt conditions. We show that a cluster phase emerges as a result of a competition between a long-range screened Coulomb repulsion and a short-range attraction. A simple effective potential, in which electrostatic repulsion is fixed by experimental conditions and attraction is modeled with a generalized Lennard-Jones potential, accounts in a remarkable way for the wavevector dependence of the X-ray scattering structure factor.
PACS: 87.14.Ee – Proteins / 61.10.Eq – X-ray scattering (including small-angle scattering) / 61.20.Ja – Computer simulation of liquid structure
© Europhysics Letters Association, 2007
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