Volume 78, Number 3, May 2007
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||17 April 2007|
Lateral diffusion of receptor-ligand bonds in membrane adhesion zones: Effect of thermal membrane roughness
Max Planck Institute of Colloids and Interfaces - 14424 Potsdam, Germany
2 University Linz - Altenbergerstr. 69, 4040 Linz, Austria
Accepted: 18 March 2007
The adhesion of cells is mediated by membrane receptors that bind to complementary ligands in apposing cell membranes. It is generally assumed that the lateral diffusion of mobile receptor-ligand bonds in membrane-membrane adhesion zones is slower than the diffusion of unbound receptors and ligands. We find that this slowing-down is not only caused by the larger size of the bound receptor-ligand complexes, but also by thermal fluctuations of the membrane shape. We model two adhering membranes as elastic sheets pinned together by receptor-ligand bonds and study the diffusion of the bonds using Monte Carlo simulations. In our model, the fluctuations reduce the bond diffusion constant in planar membranes by a factor close to 2 in the biologically relevant regime of small bond concentrations.
PACS: 87.16.Dg – Membranes, bilayers, and vesicles / 87.15.Vv – Diffusion / 68.35.Np – Adhesion
© Europhysics Letters Association, 2007
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.