| Issue |
EPL
Volume 79, Number 5, September 2007
|
|
|---|---|---|
| Article Number | 58001 | |
| Number of page(s) | 6 | |
| Section | Interdisciplinary Physics and Related Areas of Science and Technology | |
| DOI | https://doi.org/10.1209/0295-5075/79/58001 | |
| Published online | 31 July 2007 | |
Dynamic force spectroscopy of a single condensed DNA
1
Department of Physics, the University of Tokyo - 113-0033 Tokyo, Japan
2
Physics Department, Technical University Munich - 85748 Garching, Germany
Corresponding author: murayama@daisy.phys.s.u-tokyo.ac.jp
Received:
16
February
2007
Accepted:
5
July
2007
The dynamic force vs. the extension relationship of single DNA molecules in the presence of trivalent cation, spermidine, is studied using optical tweezers. A hysteresis between the stretching and relaxing cycles increases with increasing operating speed. The rate-dependent hysteresis is manifested due to the dissipative stretching and the delay of DNA condensation in the relaxing process. Effective friction inside a DNA condensate is estimated quantitatively, and its physical origin is discussed based on the Kramers-type kinetic theory.
PACS: 87.14.Gg – DNA, RNA / 87.15.He – Dynamics and conformational change / 82.37.-j – Single molecule kinetics
© Europhysics Letters Association, 2007
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