Volume 79, Number 5, September 2007
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||31 July 2007|
Dynamic force spectroscopy of a single condensed DNA
Department of Physics, the University of Tokyo - 113-0033 Tokyo, Japan
2 Physics Department, Technical University Munich - 85748 Garching, Germany
Corresponding author: firstname.lastname@example.org
Accepted: 5 July 2007
The dynamic force vs. the extension relationship of single DNA molecules in the presence of trivalent cation, spermidine, is studied using optical tweezers. A hysteresis between the stretching and relaxing cycles increases with increasing operating speed. The rate-dependent hysteresis is manifested due to the dissipative stretching and the delay of DNA condensation in the relaxing process. Effective friction inside a DNA condensate is estimated quantitatively, and its physical origin is discussed based on the Kramers-type kinetic theory.
PACS: 87.14.Gg – DNA, RNA / 87.15.He – Dynamics and conformational change / 82.37.-j – Single molecule kinetics
© Europhysics Letters Association, 2007
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