| Issue |
EPL
Volume 82, Number 2, April 2008
|
|
|---|---|---|
| Article Number | 28010 | |
| Number of page(s) | 6 | |
| Section | Interdisciplinary Physics and Related Areas of Science and Technology | |
| DOI | https://doi.org/10.1209/0295-5075/82/28010 | |
| Published online | 14 April 2008 | |
Dynamics of gene expression and the regulatory inference problem
Institut für Theoretische Physik, Universität zu Köln - Zülpicherstr. 77, 50937 Köln, Germany, EU and Kavli Institute for Theoretical Physics, UCSB - Santa Barbara, CA 93106-4030, USA
Corresponding author: berg@thp.uni-koeln.de
Received:
21
December
2007
Accepted:
5
March
2008
From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times. The decision when to express a gene is implemented by the binding and unbinding of transcription factor molecules to regulatory DNA. Here, we construct stochastic models of gene expression dynamics and test them on experimental time series data of messenger-RNA concentrations. The models are used to infer biophysical parameters of gene transcription, including the statistics of transcription factor-DNA binding and the target genes controlled by a given transcription factor.
PACS: 87.16.Yc – Regulatory genetic and chemical networks / 87.10.Mn – Stochastic modeling / 87.16.dj – Dynamics and fluctuations
© EPLA, 2008
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