Volume 83, Number 2, July 2008
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||05 July 2008|
Mean encounter times for cell adhesion in hydrodynamic flow: Analytical progress by dimensional reduction
University of Heidelberg, Bioquant 0013, Im Neuenheimer Feld 267 - D-69120 Heidelberg, Germany, EU
Corresponding author: Ulrich.Schwarz@bioquant.uni-heidelberg.de
Accepted: 3 June 2008
For a cell moving in hydrodynamic flow above a wall, translational and rotational degrees of freedom are coupled by the Stokes equation. In addition, there is a close coupling of convection and diffusion due to the position-dependent mobility. These couplings render calculation of the mean encounter time between cell surface receptors and ligands on the substrate very difficult. Here we show for a two-dimensional model system how analytical progress can be achieved by treating motion in the vertical direction by an effective reaction term in the mean first passage time equation for the rotational degree of freedom. The strength of this reaction term can either be estimated from equilibrium considerations or used as a fit parameter. Our analytical results are confirmed by computer simulations and allow to assess the relative roles of convection and diffusion for different scaling regimes of interest.
PACS: 82.39.-k – Chemical kinetics in biological systems / 47.15.G- – Low-Reynolds-number (creeping) flows / 05.10.Gg – Stochastic analysis methods (Fokker-Planck, Langevin, etc.)
© EPLA, 2008
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