Volume 83, Number 6, September 2008
|Number of page(s)||5|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||10 September 2008|
Numerical study of IP3-dependent Ca2+ spiral waves in Xenopus oocytes
Department of Physics and Institute of Biophysics, Huazhong Normal University - Wuhan 430079, China
2 College of Science, China University of Mining and Technology - Xuzhou 221008, China
3 Department of Physics, Lanzhou University of Technology - Lanzhou 730050 China
Corresponding authors: firstname.lastname@example.org email@example.com
Accepted: 29 July 2008
Based on a spatial extended Tang-Othmer Ca2+ model, intracellular Ca2+ spiral waves in Xenopus oocytes are numerically studied. Results show that the spiral dynamics depends on the concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP3). Varying the IP3 concentration, the spiral dynamics undergoes transitions from rigidly rotating spiral waves to meandering ones, even the spiral waves cannot exist in the system for large or little enough IP3 concentration. Understanding the dependence of spiral dynamics on IP3 concentration provides us theoretical clue to control the spiral waves through changing the IP3 concentration in experiments.
PACS: 87.10.Ed – Biological and medical physics: Ordinary differential equations (ODE), partial differential equations (PDE), integrodifferential models / 82.40.Ck – Pattern formation in reactions with diffusion, flow and heat transfer / 87.17.Aa – Modeling, computer simulation of cell processes
© EPLA, 2008
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