Volume 84, Number 3, November 2008
|Number of page(s)||3|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||14 October 2008|
How gene colocalization can be optimized by tuning the diffusion constant of transcription factors
Laboratoire de Physique Théorique de la Matière Condensée (UMR 7600), Université Paris 6 4 Place Jussieu, 75255 Paris Cedex, France, EU
Corresponding author: firstname.lastname@example.org
Accepted: 16 September 2008
We introduce an analytical model which shows quantitatively that gene colocalization significantly accelerates the association of transcriptions factors (TFs) with their target site on DNA. This model takes into account the influence of conformational fluctuations of TFs on reactivity, and shows that the benefit due to colocalization, highlighted by Kolesov et al. (Proc. Natl. Acad. Sci. U.S.A., 104 (2007) 13948), can be further optimized by tuning the diffusion coefficient of TFs. This diffusion optimized colocalization mechanism is robust and compatible with available experimental data, and could help understanding the observed gene transcription efficiency.
PACS: 87.10.Mn – Stochastic modeling / 87.15.R- – Reactions and kinetics / 05.40.Jc – Brownian motion
© EPLA, 2008
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