Volume 84, Number 5, December 2008
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||12 December 2008|
Collective vesicle transport on biofilaments carried by competing molecular motors
Departament de Fisica Fonamental, Universitat de Barcelona - Carrer Martí i Franqués 1, 08028-Barcelona, Spain, EU
Corresponding author: firstname.lastname@example.org
Accepted: 3 November 2008
We study a minimal model for bidirectional collective transport of cargo vesicles on a biofilament where the competing motion is characterized by the cargo densities moving toward the opposite filament ends. The model incorporates inter-vesicle interaction (through excluded volume) and active transport as well as motor regulation and environment interactions. From the current profiles we derive the non-equilibrium phase diagram. In terms of the filament end cargo fluxes, the phase diagram allows for re-emergent density shocks. This approach captures qualitatively a number of features of the collective state of the cargoes associated with bidirectional transport: current reversals due to internal regulation, boundary induced phase transitions and domain wall localization in the bulk. Vesicle polarization emerges naturally within the proposed framework.
PACS: 87.10.-e – General theory and mathematical aspects / 87.16.A- – Theory, modeling, and simulations / 87.16.Nn – Motor proteins (myosin, kinesin dynein)
© EPLA, 2008
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