Volume 85, Number 6, March 2009
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||01 April 2009|
Charge transport in bacteriorhodopsin monolayers: The contribution of conformational change to current-voltage characteristics
Dipartimento di Ingegneria dell'Innovazione, Università del Salento - via Arnesano, I-73100 Lecce, Italy, EU
2 CNISM, Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia via della Vasca Navale 84, I-00146 Roma, Italy, EU
Corresponding author: email@example.com
Accepted: 23 February 2009
When moving from native to light-activated bacteriorhodospin, modification of charge transport consisting of an increase of conductance is correlated to the protein conformational change. A theoretical model based on a map of the protein tertiary structure into a resistor network is implemented to account for a sequential tunneling mechanism of charge transfer through neighbouring amino acids. The model is validated by comparison with current-voltage experiments. The predictability of the model is further tested on bovine rhodopsin, a G-protein coupled receptor (GPCR) also sensitive to light. In this case, results show an opposite behaviour with a decrease of conductance in the presence of light.
PACS: 87.85.jc – Electrical, thermal, and mechanical properties of biological matter / 87.15.hp – Conformational changes / 87.10.Rt – Monte Carlo simulations
© EPLA, 2009
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