| Issue |
EPL
Volume 86, Number 6, June 2009
|
|
|---|---|---|
| Article Number | 68003 | |
| Number of page(s) | 6 | |
| Section | Interdisciplinary Physics and Related Areas of Science and Technology | |
| DOI | https://doi.org/10.1209/0295-5075/86/68003 | |
| Published online | 13 July 2009 | |
The effect of inhomogenities on single-molecule imaging by hard XFEL pulses
Research Institute for Solid State Physics and Optics - H-1525 Budapest, POB 49, Hungary, EU
Corresponding author: jurek-z@szfki.hu
Received:
5
March
2009
Accepted:
9
June
2009
We study the local distortion of the atomic structure in small biological samples illuminated by X-ray free electron laser (XFEL) pulses. We concentrate on the effect of inhomogenities: heavy atoms in a light matrix and non-homogeneous spatial distribution of atoms. In biological systems we find both. Using molecular-dynamics
type modeling it is shown that the local distortions about heavy atoms are larger than the average distortion in the light matrix. Further it is also shown that the large spatial density fluctuations also significantly alter the time evolution of atomic displacements as compared to samples with uniform density. This fact has serious consequences on single-particle imaging. This is discussed and the possibility of a correction is envisaged.
PACS: 87.15.ap – Molecular dynamics simulation / 87.15.B- – Structure of biomolecules / 87.53.-j – Effects of ionizing radiation on biological systems
© EPLA, 2009
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.