Global cross-over dynamics of single semiflexible polymers

Department of Physics, Technical University of Munich - 85748 Garching, Germany, EU

Corresponding author: mhinczewski@ph.tum.de

Received: 23 July 2009
Accepted: 16 September 2009

Abstract

We present a mean-field dynamical theory for single semiflexible polymers which can precisely capture, without fitting parameters, recent fluorescence correlation spectroscopy results on single-monomer kinetics of DNA strands in solution. Our approach works globally, covering three decades of strand length and five decades of time: it includes the complex cross-overs occurring between stiffness-dominated and flexible bending modes, along with larger-scale rotational and center-of-mass motion. The accuracy of the theory stems in part from long-range hydrodynamic coupling between the monomers, which makes a mean-field description more realistic. Its validity extends even to short, stiff fragments, where we also test the theory through Brownian hydrodynamics simulations.