Volume 88, Number 3, November 2009
|Number of page(s)||5|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||11 November 2009|
Anomalous diffusion in the presence of mobile obstacles
Deutsches Krebsforschungszentrum - D-69120 Heidelberg, Germany, EU
2 Softmatter Lab, Department of Physics and ITPA, Xiamen University - Xiamen 361005, PRC
3 Leibniz-Institut für Polymerforschung Dresden - 01069 Dresden, Germany, EU
Corresponding author: email@example.com
Accepted: 13 October 2009
In this letter a lattice model for the diffusional transport of binding proteins in a dynamic chromatin fiber network is proposed. Dynamic dense networks are created by a combined version of the bond fluctuation method and a Metropolis Monte Carlo algorithm. In the presence of binding affinities between protein and chromatin transient subdiffusion occurs for small particles. However, by comparing diffusion of binding particles in a static and a dynamic chain network, we demonstrate that binding properties do have a much stronger influence on particles in the static chain network than in the dynamic chain network: fluctuations of the chromatin fiber network weaken the effect of binding affinities on the diffusional transport of particles, i.e. in the presence of chromatin fluctuations the transport of small binding proteins is less anomalous. At the same time we show that dynamical fibers speed up the transport of binding proteins.
PACS: 87.15.Vv – Diffusion / 87.15.aK – Monte Carlo simulations / 87.15.hg – Dynamics of intermolecular interactions
© EPLA, 2009
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.