Volume 88, Number 4, November 2009
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||03 December 2009|
Adaptive gene regulatory networks
Institut für Theoretische Physik, Universität zu Köln - Zülpicher Straße 77, 50937 Köln, Germany, EU
2 Physikalisches Institut, Albert-Ludwigs-Universität Freiburg - Herrmann Herder-Str. 3, 79104 Freiburg, Germany, EU
Corresponding author: firstname.lastname@example.org
Accepted: 5 November 2009
Regulatory interactions between genes show a large amount of cross-species variability, even when the underlying functions are conserved: there are many ways to achieve the same function. Here we investigate the ability of regulatory networks to reproduce given expression levels within a simple model of gene regulation. We find an exponentially large space of regulatory networks compatible with a given set of expression levels, giving rise to an extensive entropy of networks. Typical realisations of regulatory networks are found to share a bias towards symmetric interactions, in line with empirical evidence.
PACS: 87.16.Yc – Regulatory genetic and chemical networks / 87.23.Kg – Dynamics of evolution / 87.18.Sn – Neural networks and synaptic communication
© EPLA, 2009
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